A selection of DNA damaging HPAPI toxins and intermediates are available to purchase directly from Apex Molecular. These compounds are synthesised in our laboratories.

We also have experience in producing toxin-linker constructs utilising toxins classes, such as PDBs, Duocarmycins, Auristatins and Camptothecin analogues i.e Exatecan and SN-38

 

 

PBDs & Intermediates

Structure Name CAS Spec Quantity
4-Benzyloxy-5-methoxy-2-nitrobenzoic acid 60547-92-4 >95% 5 g
10 g
20 g
bulk
Tomaymycin 81422-30-2 >95% 10 mg
25 mg
100 mg
bulk
Tomaymycin DM 945490-09-5 >95% 10 mg
25 mg
100 mg
bulk
DC-81 81307-24-6 >95% 10 mg
25 mg
100 mg
bulk

 

Duocarmycins & Intermediates

Structure Name CAS Spec Quantity
N-Boc-O-benzyl-seco-CBI 128300-11-8 >95% 250 mg
500 mg
1 g
bulk
N-Boc-seco-CBI 130007-86-2 >95% 10 mg
250 mg
500 mg
1 g
bulk
Duocarmycin TM 157922-77-5 >95% 10 mg
25 mg
100 mg
bulk
Duocarmycin MB 1613286-58-0 >95% 10 mg
25 mg
100 mg
bulk

Auristatin Intermediates

Structure Name CAS Spec Quantity
N-Boc-Dil 132149-81-6 >95% 1 g
2 g
5 g
10 g
N-Boc-Dap 120205-50-7 >95% 1 g
5 g