Facilities

Labs

Equipment

General
Chemistry

• 40+ Fumehoods
• 8000 sq ft lab and office facilities
• Plumbed-in argon and nitrogen services
• Dedicated High Vacuum system
• Home Office Licence for Controlled Substances Schedule 1 to Schedule 4
• Fully serviced fumehoods with Firetrace® Fire Suppression System
• Solvent and Chemicals Store

Discovery
Chemistry

• 6- and 12-place Radley™ Carousel Reactors
• Parallel hydrogenator (up to 7 x 20 mL reactors)
• Biotage™ automated microwave synthesis system
• Lab2B Ozone generator
• HepatoChem EvoluChem Photoreactor
• Biotage™ automated chromatography kit
• 2 x Teledyne ISCO CombiFlash® automated chromatography kit
• PuriFlash® automated chromatography kit

Development &
Scale-up Chemistry

• Scale-up jacketed reactors up to 20 L
• Low and high temperature control (-78°C-200°C)
• 1 L Pressure hydrogenator (up to 10 bar)

Highly Potent
Chemistry

• Clean room with four-glove negative pressure isolator
• Wet chemistry laboratory with three fumehoods
• Separate gowning area
• Controlled access to high potency facilities
• Plumbed nitrogen and compressed air services
• Dedicated air handling system operated under negative pressure cascade

Analytical Capabilities

Our facilities include:

• 3 x Water H-Class UPLCMS with PDA/QDa detectors providing rapid reaction monitoring and final compound purity assessment methodology
• Waters preparative HPLC system
• Bruker 400 MHz NMR

Access to:

• 2 x Acquity H-Class with PDA/QDa detectors providing rapid reaction monitoring and final compound purity assessment methodology
• FractionLynx Autopurify system with PDA/QDa detection for intermediate and final compound mass directed purification (10 mg to 1 g scale)
• Bruker™ NMR (500 MHz)
• Interface across all system provided via a simple Open Access platform

Wider site – facilities and partners

Our analytical facilities also include:

• Varian™ GCMS
• Particle size analyser
• Bruker™ NMR (400 MHz)

Our information resources include:

• Library Facilities
• Online access to a number of journals and the British Library
• Reaction database search capability with SciFinder®