Our modern laboratory facilities are highly serviced and flexible enabling us to meet our customers’ needs across the pre-clinical early development phases – from milligrams to hundreds of grams.

Labs

We can operate across the lab scale from mL to 20 L and synthesise mg to small Kgs of target compounds. We are equipped to carry out most modern chemistries including low and high temperature reactions, hydrogenations, carbonylations, alkylations, cross coupling chemistries and microwave chemistry.

Equipment

General
Chemistry

  • 20+ Fumehoods
  • 168 m2 lab and office facility
  • Plumbed-in argon and nitrogen services
  • Dedicated High Vacuum system
  • Home Office Licence for Controlled Substances Schedule 1 to Schedule 4
  • Fully serviced fumehoods with Firetrace® Fire Suppression System

Discovery
Chemistry

  • 6- and 12-place Radley™ Carousel Reactors
  • Parallel hydrogenator (up to 7 x 20 mL reactors)
  • Biotage™ automated microwave synthesis system
  • Biotage™ and Isco automated chromatography kit

Development &
Scale-up Chemistry

  • Scale-up jacketed reactors up to 20 L
  • Low and high temperature control (-78°C-200°C)
  • 1 L Pressure hydrogenator (up to 10 bar)

Highly Potent
Chemistry

  • Clean room with four-glove negative pressure isolator
  • Wet chemistry laboratory with three fumehoods
  • Separate gowning area
  • Controlled access to high potency facilities
  • Plumbed nitrogen and compressed air services
  • Dedicated air handling system operated under negative pressure cascade

Analytical Capabilities

Our facilities include:

  • Water ZQ2000 LCMS
  • Waters preparative HPLC system
  • 2 x Acquity H-Class with PDA/QDa detectors providing rapid reaction monitoring and final compound purity assessment methodology
  • FractionLynx Autopurify system with PDA/QDa detection for intermediate and final compound mass directed purification (10 mg to 1 g scale)
  • UPC2 with PDA/QDa detectors for Chiral screening and QC work as well as orthogonal achiral analysis
  • Interface across all system provided via a simple Open Access platform

Wider site – facilities and partners

Our analytical facilities also include:

  • Varian™ GCMS
  • Particle size analyser
  • Bruker™ NMR (500 MHz)

Our information resources include:

  • Library Facilities
  • Online access to a number of journals and the British Library
  • Reaction database search capability with SciFinder®