Apex Molecular is a leading UK Chemistry CRO providing specialist chemistry services, including the synthesis of high potency warhead and payload compounds for use in Antibody Drug Conjugates (ADCs).

The Apex Molecular Advantage

  • Expertise in the synthesis of HP small molecules offering upstream synthesis of cytotoxins for the Antibody Dug Conjugates (ADCs) market
  • Combination of toxin-linker for development of novel payloads
  • Capability and expertise to synthesise compounds on up to small gram scale to support pre clinical research and development
  • All chemistry staff PhD level organic chemists
  • Selection of Antibody Drug Conjugate (ADC) related products available from stock, both toxins (e.g. Duocarmycins, PBDs) and linkers (e.g. cleavable peptide derivatives such as Boc-Val-Ala-PAB-PNP)
  • Clean room with isolator independently tested and operates at OEL < 1ng.m3 as an 8 hour time weighted average (TWA) allowing containment of most potent HPAPIs
  • Separate wet chemistry lab dedicated to high potency synthesis
  • Air handling system that operates under negative pressure cascade
  • Detailed safety protocols, standard operating procedures and full risk assessments carried out
  • Fully trained staff
  • Analytical capabilities include 400 MHz NMR and LCMS
  • Customer confidentiality and IP protection guaranteed
  • Customers include technology developers for toxins, linkers, antibodies and Antibody Drug Conjugates (ADCs)
  • Single point of contact and clear customer communication and project updates to ensure all information is shared to allow project decisions to be taken efficiently
  • Bespoke solutions to our customers’ research project challenges through flexible project execution

Please complete the contact form to receive additional information or book a call from one of our technical experts.