Your Company Molecule
Accelerate Your ADC Pipeline with Novel Synthesis
Specialised small molecule synthesis and conjugation expertise for startups and biotechs developing next-generation Antibody-Drug Conjugates (ADCs).
The Bridge Between Discovery and Clinic
Solving the most complex synthetic challenges for emerging biotech.
Synthetic Complexity
Handling highly potent and novel payload classes (PBD, Auristatins, Dolastatins) requiring specialized containment and synthesis protocols.
Rapid Iteration
Startups need fast, reliable synthesis of gram-scale materials for pilot batches, toxicology studies, and IND-enabling studies.
Seamless Transition
We offer expertise in linker technology and site-specific conjugation to ensure successful, scalable ADC construct formation.
Our Chemical Advantage
Advanced ADC Synthesis Platforms
Payload Synthesis & Handling
We specialise in the complex, multi-step synthesis of highly potent cytotoxic payloads. Our facilities adhere to strict safety and containment protocols, enabling us to work with novel mechanisms of action that others avoid.
✓ Gram-to-Kilogram scale expertise.
✓ Tubulin Inhibitors (Auristatins, Maytansinoids).
✓ DNA-targeting agents (PBD Dimers, Duocarmycins).
✓ Novel & Proprietary Payload Derivatization.
Linker Chemistry & Conjugation
The linker is critical to stability and efficacy. Our team designs and synthesizes proprietary cleavable and non-cleavable linkers, optimized for specific conjugation chemistries and therapeutic profiles.
✓ Peptide-cleavable (Val-Cit) and pH-sensitive linkers.
✓ Maleimide, Hydrazone, and Click Chemistry handles.
✓ Optimization for Drug-to-Antibody Ratio (DAR).
✓ Rapid scale-up of key linker intermediates.
Why Biotechs Choose Our Team
Expertise, confidentiality, open communication, and speed tailored for small teams.
Decades of Experience
Our senior chemists have a proven track record in delivering payload and linker components for ADC projects.
Proprietary Protection
Strict IP and confidentiality protocols—your novel chemistry is safe with us.
Flexible Partnership
Tailored project management and rapid capacity scaling to match your discovery pace.
Seamless Hand-off
High-purity, documented material synthesis ready for your conjugation phase or CMO.
Ready to Discuss Your Novel Payload?
Connect directly with our experts to evaluate your project’s feasibility and accelerate your path to the clinic.
Request a Confidential Consultation
All inquiries are handled under strict confidentiality. We look forward to powering your innovation.
Apex Molecular Ltd
Alderley Park
Mereside
Alderley Edge
SK10 4TG, UK
info@apexmolecular.com 
01625 238885
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